Base de dados : HANSEN
Pesquisa : AVALIACAO DE MEDICAMENTOS [Descritor de assunto]
Referências encontradas : 6 [refinar]
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  1 / 6 HANSEN  
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Id:24859
Autor:Baccaredda Boy, A & G Farris
Título:Treatment of leprosy with viomycin pyrazinamide and cycloserine
ver-
Fonte:Genova; s.n; 1958. 3 p. .
Descritores:HANSENIASE VIRCHOWIANA/terap
VIOMICINA/admin
VIOMICINA/farmacol
VIOMICINA/tox
VIOMICINA/uso
terap
PIRAZINAMIDA/admin
PIRAZINAMIDA/farmacol
PIRAZINAMIDA/tox
PIRAZINAMIDA/uso terap
RESULTADO DE TRATAMENTO
 TOXICIDADE DE DROGAS
 AVALIACAO DE MEDICAMENTOS/métodos
 AVALIACAO DE MEDICAMENTOS/util
Limites:HUMANO
Localização:BR191.1; 01494/s


  2 / 6 HANSEN  
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Id:18516
Autor:Newton, Sandra M; Lau, Clara; Gurcha, Sudagar S; Besra, Gurdyal S; Wright, Colin W
Título:The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis
..-
Fonte:s.l; s.n; 2002. 11 p. ilus, tab.
Resumo:Extracts from forty-three plant species were selected on account of reported traditional uses for the treatment of TB and/or leprosy. These were assayed for antimycobacterial activities. A simple in vitro screening assay was employed using two model species of mycobacteria, M. aurum and M. smegmatis. Crude methanolic extracts from three of the plants, C. mukul, P. corylifolia and S. canadensis, were found to have significant antimycobacterial activity against M. aurum only (MIC=62.5 microg/ml). Bioassay guided fractionation led to the isolation of two known benzophenanthridine alkaloids, sanguinarine (1) and chelerythrine (2), from the roots S. canadensis and the known phenolic meroterpene, bakuchiol (3) from the seeds of P. corylifolia. The fractionation of the resin of C. mukul lead to a decrease in antimycobacterial activity and hence further work was not pursued. Compound (2) was the most active against M. aurum and M. smegmatis (IC(50)=7.30 microg/ml [19.02 microM] and 29.0 microg/ml [75.56 microM], respectively). M. aurum was the most susceptible organism to all three compounds. No significant difference in antimycobacterial activity was observed when the two alkaloids were tested for activity in media of differing pH values. The activities of the pure compounds against M. aurum were comparable with those against M. bovis BCG with compound (2) being the most active (M. bovis BCG, IC(50)=14.3 microg/ml [37.3 microM]). These results support the use of these plants in traditional medicine. (AU).
Descritores:ANTITUBERCULOSOS/isol
ANTITUBERCULOSOS/uso terap
AVALIACAO DE MEDICAMENTOS/métodos
HANSENOSTATICOS/isol
HANSENOSTATICOS/uso terap
MYCOBACTERIUM/ef drogas
EXTRATOS VEGETAIS/uso terap
MEDICINA TRADICIONAL
FITOTERAPIA
Psoralea
Limites:HUMANO
SUPPORT, NON-U.S. GOV'T
Meio Eletrônico: - .
Localização:BR191.1; 09050/s


  3 / 6 HANSEN  
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Id:17947
Autor:Ramu, G; Sreevatsa; Sengupta, U; Desikan, K. V
Título:Evaluation of multiple regimens in leprosy
..-
Fonte:s.l; s.n; apr. 1981. 7 p. tab, graf.
Resumo:Assessment of bacteraemia has been made at weekly intervals in 36 lepromatous leprosy patients who were put on different antileprosy drug under four regimens, viz., DDS alone, DDS in combination with rifampicin (DDS + RIF), clofazimine (DDS + CLF) and thiacetazone (DDS + TCT). In general, with the continuation of treatment the bacillary load in the blood decreased considerably while bacteriological index (BI) of the skin remained constant during the study. No significant difference was noted in M. leprae clearance from blood between the groups treated with DDS alone and groups treated in combination with CLF and TCT. However, DDS + RIF treatment was most efficient in clearing acid-fast bacilli (AFB) from blood as compared to those noted with other drug regimens.(AU).
Descritores:HANSENIASE/quimioter
RIFAMPINA/admin
SEPTICEMIA/quimioter
QUIMIOTERAPIA COMBINADA
DAPSONA/ef adv
TIOACETAZONA/admin
CLOFAZIMINA/admin
AVALIACAO DE MEDICAMENTOS
Limites:ESTUDO COMPARATIVO
HUMANO
MASCULINO
Meio Eletrônico: - .
Localização:BR191.1; 00696/s


  4 / 6 HANSEN  
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Id:17866
Autor:Aronne Benach, M. T; Naranjo Cascante, G
Título:Estudio de biodisponibilidad en dos preparaciones distintas de rifampicina
Bioavailability of 2 different rifampicin preparations-
Fonte:s.l; s.n; October 15, 1980. 4 p. tab, graf.
Resumo:Blood levels of two different preparations of Rifampicin were determined after a standard dose of 600mg. Three hours later, blood concentrations showed no statistical differences. Six hours later the levels were statiscally significant well above the minimum inhibitory levels for Mycobacterium Tuberculosis. For practical purposes it may be said that no diference in th bioavailability existis between the two drugs studied...(AU).
Descritores:ABSORCAO INTESTINAL
FATORES DE TEMPO
DISPONIBILIDADE BIOLOGICA
ENSAIOS CLINICOS
AVALIACAO DE MEDICAMENTOS
RIFAMPINA/sangue
RIFAMPINA/metab
RIFAMPINA/urina
Limites:HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
ADOLESCENTE
RESUMO EM INGLES
Meio Eletrônico: - .
Localização:BR191.1; 00679/s


  5 / 6 HANSEN  
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Id:13841
Autor:Lombardi, Clovis; Pedrazzani, Elizete Silva; Pedrazzani, Joao Carlos; Ferreira Filho, Pedro; Zicker, Fabio
Título:Eficacia protectora del BCG contra la lepra en Sao Paulo, Brasil
?-
Fonte:s.l; s.n; 1995. 7 p. tab.
Descritores:HANSENIASE
HANSENIASE
VACINA BCG
AVALIAÇAO DE MEDICAMENTOS
ESTATISTICA
Localização:BR191.1; 06826/s


  6 / 6 HANSEN  
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Id:1876
Autor:Navarrete Aldama, Yucando
Título:Quimioterapia de la lepra: estudio comparativo de cinco medicamentos
..-
Fonte:Mexico; s.n; 1967. 62 p. ilus, 27cm.
Tese:Apresentada a Universidad Nacional Autónoma de México. Facultad de Medicina para obtenção do grau de Doutor.
Resumo:En las óltimas décadas se hen realizado progresos importantes en el campo de la enfermos hansenianos. El objeto de este trabajo es evaluar la actividad terapéutica de los medicamentos más recientemente adquiridos, haciendo su comparación con el medicamento que ha sido de elección, la Diaminodifenilsulfona o DDS, en el tratamiento de la lepra. Se hace una revisión somera del concepto actual de la enfermedad, de los estudios más recientes tendienentes a dilucidar los misterios de la infección leprosa, de su clasificación, diagnóstico y pronóstico, y con especial interés se revisa la literatura existente acerca del tratamiento de la lepra, desde sus aspectos generales y quimioterapia, abarcando la era presulfónica, sulfónica, hasta adelantos más recientes, Se hace la evaluación terapéutica de la Difeniltiourea, Sulfametoxipiridazina, isoxyl CP y Ro 4-4393, teniendo como patrón de comparación a la Diaminodifenilsulfona a DDS. Se estudian los espectos quimicos, farmacológicos, la toxicidad, los usos, los resultados clinicos y de laboratorio de los diferentes autores tanto extranjeros como de nuestro pais(AU).
Descritores:HANSENIASE
HANSENIASE
HANSENIASE
HANSENIASE
ANTIBIOTICOPROFILAXIA
ESTUDOS DE CASOS E CONTROLES
AVALIAÇAO DE MEDICAMENTOS
Localização:BR191.1; WC335.900.10, 227q



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